Acute toxicity study of tilmicosin-loaded hydrogenated castor oil-solid lipid nanoparticles

Preparation and evaluation of tilmicosin-loaded hydrogenated castor oil nanoparticle suspensions of different particle sizes

Three tilmicosin-loaded hydrogenated castor oil nanoparticle (TMS-HCO-NP) suspensions of different particle sizes were prepared with different polyvinyl alcohol surfactant concentrations using a hot homogenization and ultrasonic technique. The in vitro release, in vitro antibacterial activity, mammalian cytotoxicity, acute toxicity in mice, and stability study were conducted to evaluate the cha...

characterization of zataria multiflora essential oil loaded solid lipid nanoparticles

Cytotoxicity of Tamoxifen-Loaded Solid Lipid Nanoparticles

Breast cancer is one the most important health concerns of the modern society (Ferlay et al., 2007). Worldwide, it is estimated that over one million new cases of breast cancer are diagnosed every year, and more than 400 thousands will die from the breast cancer (Coughlin & Ekwueme, 2009) The life-time risk in women contracting breast cancers is estimated to be 1 in 8, which is the highest amon...

Antifungal activity of Zataria multiflora essential oil-loaded solid lipid nanoparticles in-vitro condition

Objective(s): The aim of the present study was to prepare, characterize, and evaluate solid lipid nanoparticles (SLNs) containing Zataria multiflora essential oil (ZEO). Materials and Methods: In this study, Z. multiflora essential oil-loaded solid lipid nanoparticles (ZE-SLNs) were prepared to improve its efficiency in controlling some fungal pathogens. SLNs containing Z. multiflora essential ...

Sustained release Curcumin loaded Solid Lipid Nanoparticles.

PURPOSE curcumin is poorly water soluble drug with low bioavailability. Use of lipid systems in lipophilic substances increases solubility and bioavailability of poorly soluble drugs. The aim of this study was to prepare curcumin loaded Solid Lipid Nanoparticles (SLNs) with high loading efficiency, small particle size and prolonged release profile with enhanced antibacterial efficacy. METHODS...